ISBN 9783843924023

978-3-8439-2402-3, Reihe Analytische Chemie

Mariana Neves Vieira
Studies on the use of countercurrent chromatography for the preparative isolation and identification of natural compounds active against Neglected Tropical Diseases.

245 Seiten, Dissertation Technische Universität Braunschweig (2015), Hardcover, A5

Zusammenfassung / Abstract

Countercurrent Chromatography is a versatile separation technique, especially used in the field of natural product isolation. Neglected tropical diseases (NTDs) are a group of infections that predominantly affect the poorest and most vulnerable populations. New drugs for the therapy and control of NTDs are urgently needed and natural products may offer an easily accessible, less toxic and sustainable source of bioactive chemicals. Therefore, the present project aimed to contribute by optimizing analytical methods that could be useful for the purification of lead natural compounds for the discovery of new drugs against NTDs.