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978-3-8439-2633-1, Reihe Medizin

Monika Schaubeck
Characterization of transferable intestinal dysbiosis in murine Crohn's Disease Ileitis

105 Seiten, Dissertation Technische Universität München (2016), Softcover, A4

Zusammenfassung / Abstract

Dysbiosis” of microbial communities is assumed to play a crucial role in the development of diverse pathologies, including inflammatory bowel diseases (IBD). Dysbiosis is commonly defined by compositional alterations of symbiotic microbial ecosystems with detrimental consequences for the host. The characteristics of dysbiotic ecosystems and the interrelated mechanisms of microbe-host interaction are still to be designated. Additionally, functional evidence for a causal role of dysbiosis in development of pathology is not provided, yet. Dysbiotic shifts in the gut ecosystem are repeatedly assumed to be causal for development of IBD, which is characterized by an overreaction of the immune system towards intestinal commensals. Especially for ileitis, as found in Crohn´s disease (CD), few data are available for the role of microbial triggers in development of inflammation. Consequently, the aim of the present study was to test the causal role and characteristics of dysbiosis in a genetically modified animal model of spontaneous ileal pathology.