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ISBN 9783843905541

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978-3-8439-0554-1, Reihe Organische Chemie

Dimitrios Stathis
Oxidative DNA Damage: From Lesion Chemistry to Biological Implications

162 Seiten, Dissertation Ludwig-Maximilians-Universität München (2012), Softcover, A5

Zusammenfassung / Abstract

This book focuses on the oxidation chemistry of guanosine and gives emphasis to the reaction pathways mediating its oxidative degradation. Targeting towards a deeper understanding of the intermediate species mediating this process and their consequences in fundamental cellular mechanisms, such as replication and transcription, exciting discoveries both in the side of chemistry and its biological implications are revealed. A novel intermediate that forms during the oxidative degradation of guanosine is reported. The base-pairing properties of this new lesion, as well as its mutagenic effect when replicated by polymerases, are deciphered. The contribution of guanosine-derived compounds to the mutagenicity of reactive oxygen species damaged DNA is thus reconsidered, opening the doorway to interesting chemical and biochemical events that potentially take place in vitro and most importantly in vivo.