ISBN 9783843910170

978-3-8439-1017-0, Reihe Organische Chemie

Samet Gülak
Olefin-Assisted Iron and Cobalt Catalyzed Cross-Coupling Reactions for the Synthesis of Highly Functionalized Styrene Derivatives

213 Seiten, Dissertation Universität Regensburg (2013), Softcover, A5

Zusammenfassung / Abstract

Transition metal-catalyzed cross-coupling reactions have matured to an indispensable tool for the functionalization of aromatic molecules. While the majority of protocols utilize electrophilic aryl bromides and aryl iodides, reactions with economically more attractive aryl chlorides remain a challenge for which only a handful of catalyst system exhibit satisfactory activity. We wish to report on our efforts to design a cross-coupling reaction that takes advantage of the activation of aryl chlorides by vinyl substituents. Highly chemoselective iron- and cobalt-catalyzed cross-coupling has been observed under conditions commonly unsuitable for the consumption of deactivated aryl chlorides, while competitive side reactions (polymerization, Heck-type reactions, carbometallation) were suppressed.