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ISBN 9783843912938

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978-3-8439-1293-8, Reihe Tiermedizin

Bastian Alexander Popper
Impact of the genetic background on the development of diabetes-associated renal lesions in GIPRdn transgenic diabetic mice

155 Seiten, Dissertation Ludwig-Maximilians-Universität München (2013), Softcover, A4

Zusammenfassung / Abstract

Diabetic nephropathy is one of the most feared long-term complication of diabetes mellitus and represents the leading single cause of chronic kidney disease in humans.

The study examined the impact of different genetic backgrounds on morphological murine kidney aspects with a potential pathogenetic relevance for the development of diabetic nephropathy. Transgenic diabetic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) were bred on two different genetic backgrounds.

Clinical, functional and semiquantitative pathohistological analyses as well as quantitative-stereological investigations were performed to determine the severity of the diabetic phenotype and of associated renal alterations.