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978-3-8439-2531-0, Reihe Organische Chemie

Svetlana Botov
Synthese und Evaluation von Dien-Tricarbonyleisen(0)-Komplexen als enzymatisch aktivierbare CO-freisetzende Moleküle (ET-CORMs)

251 Seiten, Dissertation Universität Köln (2015), Softcover, A5

Zusammenfassung / Abstract

Carbon monoxide is beside nitric oxide one of the smallest natural products which has an endogenous origin and exhibits a variety of beneficial biological activities, such as cytoprotective, anti-inflammatory, vasodilatory and anti-proliferative effects. The development of CO-releasing molecules (CORMs) allows the evident biological potential of CO be used as a therapeutic. Within the scope of this work acyloxydiene-Fe(CO)3-complexes were modified in varied manner, while additional functionalities were introduced via the ester function as well as the cyclohexenyl-scaffold. Hybride ET-CORMs were synthesized in a combination with biologically active non-steroidal anti-inflammatory drugs and their effects were evaluated in cellular systems. The alkine functionalized complexes were synthesized following the concept developed by S. Romanski and, using the copper-catalyzed 1.3 dipolar cycloaddition with specifically functionalized organic azides, were transferred to the diverse triazole complexes which were subsequently evaluated as enzymatically triggered CORMs with promising biological activity.