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978-3-86853-866-3, Reihe Pharmazeutische Chemie

Mathias König
Synthese neuartiger Inhibitoren der humanen delta8,7-Sterolisomerase

296 Seiten, Dissertation Ludwig-Maximilians-Universität München (2011), Softcover, A5

Zusammenfassung / Abstract

Homogeneous catalysts based on transition metals are of high industrial relevance. An important goal for this purpose is the light-induced start of the catalytic reaction. The electronic and steric influence of the olefin ligand upon the spectroscopic properties, stability and reactivity of bistriphenylphosphine-cinnamate and related complexes of group 10 were studied in this thesis. By means of these findings a direct prediction of the reactivity was possible based on the NMR-spectroscopic behaviour. Thus a specific design of photo-switchable complexes was possible, in which the olefin ligand could be cleaved from the metal via a selective light-induced intra-ligand cyclisation. This ring closure was examined with the ligand itself as well as in the complexes, concerning electronic and steric influences.